Daim Ntawv Thov ntawm Hydroxy Methionine Tooj Liab 1

Cov Ntawv Thov Khoom

1) Cov qaib qaib

Thaum MMHACs (hydroxy methionine chelates ntawm tooj liab, zinc, thiab manganese) tau ntxiv rau hauv cov zaub mov broiler, cov txiaj ntsig tau qhia tias—piv nrog cov zaub mov inorganic ib txwm muaj—kev suav nrog MMHACs ua rau lub cev hnyav thiab cov leeg nqaij ntawm lub duav nce ntxiv, txhim kho kev zom tooj liab, thiab tsis muaj kev cuam tshuam tsis zoo rau lub plab lossis pob txha kev noj qab haus huv.

Rooj 1. Qhov hnyav ntawm kev ua cov cev nqaij daim tawv (g/noog) thiab cov qhab nia ntawm cov ntoo hauv siab thiab cov kab dawb ntawm cov qaib ntxhw uas tau noj cov tshuaj inorganic thiab methionine hydroxyl analogue chelated zinc, tooj liab, thiab manganese rau hnub Saturday hnub 42.

Khoom	ITM	M10	T125	M30	SEM	Tus nqi P
Lub mis	684	716	719	713	14.86	0.415
Lub duav	397	413	412	425	7.29	0.078
Nruas	320	335	332	340	4.68	0.058
Lub puab tsaig thiab lub nruas	717 ib	748 ab	745 ab	765 b	11.32	0.050
Cov roj pad	32.3	33.1	33.4	35.5	1.59	0.546
Siab	68.0	67.4	66.0	71.1	2.41	0.528
Lub plawv	18.8	18.6	19.2	19.2	0.68	0.898
Lub raum	9.49	10.2	10.6	10.6	0.51	0.413

Lus Cim: ITM: Cov ntxhia inorganic trace 110 ppm Zn ua ZnSO4 16 ppm Cu ua CuSO4 thiab 120 ppm Mn ua MnO ib Ross 308 cov lus qhia txog kev noj haus;

M10: Cov nqi ntawm 40 ppm Zn 10 ppm Cu thiab 40 ppm Mn ua chelate;

T125: Cov ntxhia inorganic 110 ppm Zn ua ZnSO4 thiab 120 ppm Mn ua MnO ib Ross 308 cov lus qhia nrog 125 ppm Cu ua tribasic tooj liab chloride (TBCC);

M30 = 40 ppm Zn, 30 ppm Cu, thiab 40 ppm Mn ua chelate. Cov nqi nyob rau hauv tib kab nrog cov superscripts sib txawv sib txawv heev (P < 0.05).

2) Cov npua

Ib txoj kev tshawb nrhiav tau tshawb nrhiav txog cov teebmeem ntawm kev hloov cov zaub mov inorganic trace nrog cov zaub mov methionine hydroxy analogue chelates (MMHAC) hauv cov npua npua noj rau ob tug npua npua thiab lawv cov menyuam npua. Cov txiaj ntsig tau qhia tias MMHAC kev noj tshuaj pab txo qhov hnyav ntawm cov npua npua uas tab tom pub niam mis, txhawb kom cov menyuam npua nce qhov hnyav thaum hnub 18, ua rau cov leeg nqaij pob txha histone acetylation nce ntxiv thaum yug los, thiab txo qhov kev qhia tawm ntawm ntau yam kev mob thiab kev loj hlob ntawm cov leeg nqaij. Zuag qhia tag nrho, MMHAC tau txhim kho kev noj qab haus huv ntawm txoj hnyuv thiab kev loj hlob ntawm cov leeg nqaij hauv cov menyuam npua los ntawm kev tswj hwm epigenetic thiab kev loj hlob, txhim kho lawv lub peev xwm loj hlob.

Rooj 2 Cov teebmeem ntxiv ntawm cov zaub mov methionine hydroxy analogue chelate hauv cov zaub mov npua ntawm kev qhia tawm ntawm mRNA tseem ceeb ntsig txog kev o ntawm jejunal hauv cov npua me me

Khoom	ITM	CTM	SEM	P- tus nqi
d 1 ntawm kev pub niam mis x 10^-5
IL-8	1344	1018	178	0.193
MUC2	5380	5511	984	0.925
NF-κB (p50)	701	693	93	0.944
NF-κB (p105)	Xyoo 1991	1646 xyoo	211	0.274
TGF-b1	Txij li xyoo 1991	1600 xyoo	370	0.500
TNF-α	11	7	2	0.174
d 18 ntawm kev pub niam mis x 10^-5
IL-8	1134	787	220	0.262
MUC2	5773	3871	722	0.077

Lus Cim: Interleukin-8 (IL-8), mucin-2 (MUC2), nuclear factor-κB (NF-κB), transforming growth factor-1 (TGF-1), thiab tumor necrosis factor-α (TNF-α)

ITM = cov khoom siv tsis muaj organic ntawm cov zaub mov me me (0.2% qib kev suav nrog hauv cov zaub mov noj)

CTM = 50:50 cov zaub mov methionine hydroxy analogue chelate thiab cov zaub mov inorganic (0.2% qib kev suav nrog hauv cov zaub mov noj)

3)Cov tsiaj txhu uas noj zaub mov

Hauv cov nyuj mis nyuj uas pub niam mis, hloov ib nrab ntawm cov tooj liab sulfate nrogtooj liab hydroxy methionineua rau cov ntshav tooj liab ntau ntxiv, txhim kho qhov kev zom zaub mov ntawm cov tshuaj ntxuav tes tsis muaj zog (NDF) thiab cov tshuaj ntxuav tes kua qaub (ADF), thiab txhim kho ob qho tib si cov mis nyuj thiab 4% cov mis nyuj kho kom zoo. Cov kev tshawb pom no qhia tau tias kev hloov ib feem ntawm cov tooj liab sulfate nrog (HMTBA)₂-Cu hauv cov zaub mov nyuj mis nyuj yog ib txoj kev noj haus zoo dua.

Rooj 3 Cov teebmeem ntawm methionine hydroxy Cu [(HMTBA) 2-Cu] rau cov mis nyuj hauv cov nyuj

Khoom	S	SM	M	SEM	Tus nqi P
DMI, kg/hnub	19.2	20.3	19.8	0.35	0.23
Cov mis nyuj tawm, kg / d	28.8	33.8	31.3	1.06	0.08
Rog,%	3.81	3.74	3.75	0.06	0.81
Cov protein,%	3.34	3.28	3.28	0.04	0.19
Lactose,%	4.48	4.35	4.43	0.05	0.08
SNF,%	8.63	8.84	8.63	0.05	0.33
Cov roj ntau, kg / d	1.04	1.22	1.10	0.04	0.09
Cov protein ntau, kg/d	0.92	0.92	0.90	0.03	0.72
Cov txiaj ntsig ntawm lactose, kg / d	1.23	1.23	1.21	0.04	0.45
Urea N, mg/dL	18.39	17.70	18.83	0.45	0.19
4% FCM, kg/hnub	26.1	30.1	27.5	0.91	0.06

Kev Kho Mob: S = Cu sulfate xwb: 12 mg ntawm Cu muab los ntawm CuSO4 ib kilogram ntawm cov tshuaj concentrate; SM = Cu sulfate thiab (HMTBA)2-Cu: 6 mg ntawm Cu muab los ntawm CuSO4, thiab lwm 6 mg ntawm Cu muab los ntawm (HMTBA)2-Cu ib kilogram ntawm cov tshuaj concentrate; M = (HMTBA)2-Cu xwb: 12 mg ntawm Cu muab los ntawm (HMTBA)2-Cu ib kilogram ntawm cov tshuaj concentrate.